How the cortico-thalamic feedback affects the EEG power spectrum over frontal and occipital regions during propofol-induced anaesthetic sedation
Identifieur interne : 000848 ( Main/Exploration ); précédent : 000847; suivant : 000849How the cortico-thalamic feedback affects the EEG power spectrum over frontal and occipital regions during propofol-induced anaesthetic sedation
Auteurs : Meysam Hashemi [France] ; Axel Hutt [France] ; Jamie Sleigh [Nouvelle-Zélande]Source :
Abstract
Increasing concentrations of the anaesthetic agent propofol initially induces sedation before achieving full general anaesthesia. The characteristic changes in electroencephalographic (EEG) rhythms include increased activity in the δ− (1-4 Hz) and α− (8-12 Hz) frequency bands over the frontal region, but increased δ− and decreased α−activity over the occipital region. It is known that the cortex, the thalamus, and the thalamo-cortical feedback loop contribute to some degree to the propofol-induced changes in the EEG power spectrum. However the precise role of each structure to the dynamics of the EEG is unknown. In this paper we apply a neuronal population model of a single thalamo-cortical module to repro-duce the power spectrum changes in EEG during propofol-induced anaesthesia sedation. Based on recent experimental data, the effect of propofol is modelled as an increase in inhibitory synaptic response amplitude and decay time constant in thalamo-cortical relay cells while cortical inhibition is neglected. The model reproduces the power spectrum features observed experimentally both in frontal and occipital electrodes. Moreover a detailed analysis of the model indicates the importance of multiple resting states in brain activity. The work suggests that the α−activity originates from the cortico-thalamic relay interaction, whereas the emergence of δ−activity results from the full cortico-reticular-relay-cortical feedback loop with a prominent enforced thalamic reticular-relay interac-tion. This model suggests an essential role of synaptic GABAergic receptors at relay neurons and, more generally, for the thalamus in the generation of both the α− and the δ−EEG patterns that are seen during propofol anaesthesia sedation.
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The characteristic changes in electroencephalographic (EEG) rhythms include increased activity in the δ− (1-4 Hz) and α− (8-12 Hz) frequency bands over the frontal region, but increased δ− and decreased α−activity over the occipital region. It is known that the cortex, the thalamus, and the thalamo-cortical feedback loop contribute to some degree to the propofol-induced changes in the EEG power spectrum. However the precise role of each structure to the dynamics of the EEG is unknown. In this paper we apply a neuronal population model of a single thalamo-cortical module to repro-duce the power spectrum changes in EEG during propofol-induced anaesthesia sedation. Based on recent experimental data, the effect of propofol is modelled as an increase in inhibitory synaptic response amplitude and decay time constant in thalamo-cortical relay cells while cortical inhibition is neglected. The model reproduces the power spectrum features observed experimentally both in frontal and occipital electrodes. Moreover a detailed analysis of the model indicates the importance of multiple resting states in brain activity. The work suggests that the α−activity originates from the cortico-thalamic relay interaction, whereas the emergence of δ−activity results from the full cortico-reticular-relay-cortical feedback loop with a prominent enforced thalamic reticular-relay interac-tion. This model suggests an essential role of synaptic GABAergic receptors at relay neurons and, more generally, for the thalamus in the generation of both the α− and the δ−EEG patterns that are seen during propofol anaesthesia sedation.</div></front></TEI><affiliations><list><country><li>France</li><li>Nouvelle-Zélande</li></country><region><li>Grand Est</li><li>Lorraine (région)</li></region><settlement><li>Metz</li><li>Nancy</li></settlement><orgName><li>Université de Lorraine</li></orgName></list><tree><country name="France"><region name="Grand Est"><name sortKey="Hashemi, Meysam" sort="Hashemi, Meysam" uniqKey="Hashemi M" first="Meysam" last="Hashemi">Meysam Hashemi</name></region><name sortKey="Hutt, Axel" sort="Hutt, Axel" uniqKey="Hutt A" first="Axel" last="Hutt">Axel Hutt</name></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Sleigh, Jamie" sort="Sleigh, Jamie" uniqKey="Sleigh J" first="Jamie" last="Sleigh">Jamie Sleigh</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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